Brugia malayi: Comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model
Identifieur interne : 007367 ( Main/Exploration ); précédent : 007366; suivant : 007368Brugia malayi: Comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model
Auteurs : Sivasakthivel Thirugnanam [Inde] ; Pandurangan Pandiaraja [Inde] ; Kalyanasundaram Ramaswamy [États-Unis] ; Vadivel Murugan [Inde] ; Munirathinam Gnanasekar [États-Unis] ; Krithika Nandakumar [Inde] ; Maryada Venkata Rami Reddy [Inde] ; Perumal Kaliraj [Inde]Source :
- Experimental parasitology [ 0014-4894 ] ; 2007.
Descripteurs français
- KwdFr :
- ADN des helminthes (immunologie), Activation des lymphocytes, Animaux, Anticorps antihelminthe (biosynthèse), Anticorps antihelminthe (sang), Antigènes d'helminthe (génétique), Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Chambres de culture à diffusion, Cytokines (biosynthèse), Cytokines (génétique), Filariose lymphatique (), Gerbillinae, Immunisation (), Immunité cellulaire, Lymphocytes auxiliaires Th2 (immunologie), Modèles animaux de maladie humaine, Mâle, Protéines d'helminthes (génétique), Protéines d'helminthes (immunologie), Protéines recombinantes (génétique), Protéines recombinantes (immunologie), Vaccins (immunologie), Vaccins synthétiques (immunologie), Vaccins à ADN (immunologie).
- MESH :
- biosynthèse : Anticorps antihelminthe, Cytokines.
- génétique : Antigènes d'helminthe, Cytokines, Protéines d'helminthes, Protéines recombinantes.
- immunologie : ADN des helminthes, Antigènes d'helminthe, Brugia malayi, Lymphocytes auxiliaires Th2, Protéines d'helminthes, Protéines recombinantes, Vaccins, Vaccins synthétiques, Vaccins à ADN.
- sang : Anticorps antihelminthe.
- Activation des lymphocytes, Animaux, Chambres de culture à diffusion, Filariose lymphatique, Gerbillinae, Immunisation, Immunité cellulaire, Modèles animaux de maladie humaine, Mâle.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (biosynthesis), Antibodies, Helminth (blood), Antigens, Helminth (genetics), Antigens, Helminth (immunology), Brugia malayi (immunology), Cytokines (biosynthesis), Cytokines (genetics), DNA, Helminth (immunology), Diffusion Chambers, Culture, Disease Models, Animal, Elephantiasis, Filarial (prevention & control), Gerbillinae, Helminth Proteins (genetics), Helminth Proteins (immunology), Immunity, Cellular, Immunization (methods), Lymphocyte Activation, Male, Recombinant Proteins (genetics), Recombinant Proteins (immunology), Th2 Cells (immunology), Vaccines (immunology), Vaccines, DNA (immunology), Vaccines, Synthetic (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Helminth, Cytokines.
- chemical , blood : Antibodies, Helminth.
- chemical , genetics : Antigens, Helminth, Cytokines, Helminth Proteins, Recombinant Proteins.
- chemical , immunology : Antigens, Helminth, DNA, Helminth, Helminth Proteins, Recombinant Proteins, Vaccines, Vaccines, DNA, Vaccines, Synthetic.
- immunology : Brugia malayi, Th2 Cells.
- methods : Immunization.
- prevention & control : Elephantiasis, Filarial.
- Animals, Diffusion Chambers, Culture, Disease Models, Animal, Gerbillinae, Immunity, Cellular, Lymphocyte Activation, Male.
Abstract
Immunization of jirds with Bm-alt-2 elicited partial protection against challenge infection with the filarial parasite
Url:
DOI: 10.1016/j.exppara.2007.02.017
PubMed: 17442307
PubMed Central: 2763209
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002763
- to stream Pmc, to step Curation: 002762
- to stream Pmc, to step Checkpoint: 003C01
- to stream PubMed, to step Corpus: 003689
- to stream PubMed, to step Curation: 003689
- to stream PubMed, to step Checkpoint: 003689
- to stream Ncbi, to step Merge: 002668
- to stream Ncbi, to step Curation: 002668
- to stream Ncbi, to step Checkpoint: 002668
- to stream Main, to step Merge: 007518
- to stream Main, to step Curation: 007367
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>Brugia malayi</italic>: Comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model</title><author><name sortKey="Thirugnanam, Sivasakthivel" sort="Thirugnanam, Sivasakthivel" uniqKey="Thirugnanam S" first="Sivasakthivel" last="Thirugnanam">Sivasakthivel Thirugnanam</name><affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600 025, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Centre for Biotechnology, Anna University, Chennai 600 025</wicri:regionArea><wicri:noRegion>Chennai 600 025</wicri:noRegion></affiliation></author><author><name sortKey="Pandiaraja, Pandurangan" sort="Pandiaraja, Pandurangan" uniqKey="Pandiaraja P" first="Pandurangan" last="Pandiaraja">Pandurangan Pandiaraja</name><affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600 025, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Centre for Biotechnology, Anna University, Chennai 600 025</wicri:regionArea><wicri:noRegion>Chennai 600 025</wicri:noRegion></affiliation></author><author><name sortKey="Ramaswamy, Kalyanasundaram" sort="Ramaswamy, Kalyanasundaram" uniqKey="Ramaswamy K" first="Kalyanasundaram" last="Ramaswamy">Kalyanasundaram Ramaswamy</name><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Biomedical Sciences, University of Illinois, College of Medicine, Rockford, IL 61107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biomedical Sciences, University of Illinois, College of Medicine, Rockford, IL 61107</wicri:regionArea><wicri:noRegion>IL 61107</wicri:noRegion></affiliation></author><author><name sortKey="Murugan, Vadivel" sort="Murugan, Vadivel" uniqKey="Murugan V" first="Vadivel" last="Murugan">Vadivel Murugan</name><affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600 025, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Centre for Biotechnology, Anna University, Chennai 600 025</wicri:regionArea><wicri:noRegion>Chennai 600 025</wicri:noRegion></affiliation></author><author><name sortKey="Gnanasekar, Munirathinam" sort="Gnanasekar, Munirathinam" uniqKey="Gnanasekar M" first="Munirathinam" last="Gnanasekar">Munirathinam Gnanasekar</name><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Biomedical Sciences, University of Illinois, College of Medicine, Rockford, IL 61107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biomedical Sciences, University of Illinois, College of Medicine, Rockford, IL 61107</wicri:regionArea><wicri:noRegion>IL 61107</wicri:noRegion></affiliation></author><author><name sortKey="Nandakumar, Krithika" sort="Nandakumar, Krithika" uniqKey="Nandakumar K" first="Krithika" last="Nandakumar">Krithika Nandakumar</name><affiliation wicri:level="1"><nlm:aff id="A3"> Jamnalal Bajaj Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Jamnalal Bajaj Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram</wicri:regionArea><wicri:noRegion>Sevagram</wicri:noRegion></affiliation></author><author><name sortKey="Reddy, Maryada Venkata Rami" sort="Reddy, Maryada Venkata Rami" uniqKey="Reddy M" first="Maryada Venkata Rami" last="Reddy">Maryada Venkata Rami Reddy</name><affiliation wicri:level="1"><nlm:aff id="A3"> Jamnalal Bajaj Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Jamnalal Bajaj Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram</wicri:regionArea><wicri:noRegion>Sevagram</wicri:noRegion></affiliation></author><author><name sortKey="Kaliraj, Perumal" sort="Kaliraj, Perumal" uniqKey="Kaliraj P" first="Perumal" last="Kaliraj">Perumal Kaliraj</name><affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600 025, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Centre for Biotechnology, Anna University, Chennai 600 025</wicri:regionArea><wicri:noRegion>Chennai 600 025</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17442307</idno><idno type="pmc">2763209</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763209</idno><idno type="RBID">PMC:2763209</idno><idno type="doi">10.1016/j.exppara.2007.02.017</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">002763</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002763</idno><idno type="wicri:Area/Pmc/Curation">002762</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002762</idno><idno type="wicri:Area/Pmc/Checkpoint">003C01</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003C01</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">003689</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003689</idno><idno type="wicri:Area/PubMed/Curation">003689</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003689</idno><idno type="wicri:Area/PubMed/Checkpoint">003689</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003689</idno><idno type="wicri:Area/Ncbi/Merge">002668</idno><idno type="wicri:Area/Ncbi/Curation">002668</idno><idno type="wicri:Area/Ncbi/Checkpoint">002668</idno><idno type="wicri:Area/Main/Merge">007518</idno><idno type="wicri:Area/Main/Curation">007367</idno><idno type="wicri:Area/Main/Exploration">007367</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Brugia malayi</italic>: Comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model</title><author><name sortKey="Thirugnanam, Sivasakthivel" sort="Thirugnanam, Sivasakthivel" uniqKey="Thirugnanam S" first="Sivasakthivel" last="Thirugnanam">Sivasakthivel Thirugnanam</name><affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600 025, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Centre for Biotechnology, Anna University, Chennai 600 025</wicri:regionArea><wicri:noRegion>Chennai 600 025</wicri:noRegion></affiliation></author><author><name sortKey="Pandiaraja, Pandurangan" sort="Pandiaraja, Pandurangan" uniqKey="Pandiaraja P" first="Pandurangan" last="Pandiaraja">Pandurangan Pandiaraja</name><affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600 025, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Centre for Biotechnology, Anna University, Chennai 600 025</wicri:regionArea><wicri:noRegion>Chennai 600 025</wicri:noRegion></affiliation></author><author><name sortKey="Ramaswamy, Kalyanasundaram" sort="Ramaswamy, Kalyanasundaram" uniqKey="Ramaswamy K" first="Kalyanasundaram" last="Ramaswamy">Kalyanasundaram Ramaswamy</name><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Biomedical Sciences, University of Illinois, College of Medicine, Rockford, IL 61107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biomedical Sciences, University of Illinois, College of Medicine, Rockford, IL 61107</wicri:regionArea><wicri:noRegion>IL 61107</wicri:noRegion></affiliation></author><author><name sortKey="Murugan, Vadivel" sort="Murugan, Vadivel" uniqKey="Murugan V" first="Vadivel" last="Murugan">Vadivel Murugan</name><affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600 025, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Centre for Biotechnology, Anna University, Chennai 600 025</wicri:regionArea><wicri:noRegion>Chennai 600 025</wicri:noRegion></affiliation></author><author><name sortKey="Gnanasekar, Munirathinam" sort="Gnanasekar, Munirathinam" uniqKey="Gnanasekar M" first="Munirathinam" last="Gnanasekar">Munirathinam Gnanasekar</name><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Biomedical Sciences, University of Illinois, College of Medicine, Rockford, IL 61107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biomedical Sciences, University of Illinois, College of Medicine, Rockford, IL 61107</wicri:regionArea><wicri:noRegion>IL 61107</wicri:noRegion></affiliation></author><author><name sortKey="Nandakumar, Krithika" sort="Nandakumar, Krithika" uniqKey="Nandakumar K" first="Krithika" last="Nandakumar">Krithika Nandakumar</name><affiliation wicri:level="1"><nlm:aff id="A3"> Jamnalal Bajaj Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Jamnalal Bajaj Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram</wicri:regionArea><wicri:noRegion>Sevagram</wicri:noRegion></affiliation></author><author><name sortKey="Reddy, Maryada Venkata Rami" sort="Reddy, Maryada Venkata Rami" uniqKey="Reddy M" first="Maryada Venkata Rami" last="Reddy">Maryada Venkata Rami Reddy</name><affiliation wicri:level="1"><nlm:aff id="A3"> Jamnalal Bajaj Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Jamnalal Bajaj Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram</wicri:regionArea><wicri:noRegion>Sevagram</wicri:noRegion></affiliation></author><author><name sortKey="Kaliraj, Perumal" sort="Kaliraj, Perumal" uniqKey="Kaliraj P" first="Perumal" last="Kaliraj">Perumal Kaliraj</name><affiliation wicri:level="1"><nlm:aff id="A1"> Centre for Biotechnology, Anna University, Chennai 600 025, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea> Centre for Biotechnology, Anna University, Chennai 600 025</wicri:regionArea><wicri:noRegion>Chennai 600 025</wicri:noRegion></affiliation></author></analytic><series><title level="j">Experimental parasitology</title><idno type="ISSN">0014-4894</idno><idno type="eISSN">1090-2449</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (biosynthesis)</term><term>Antibodies, Helminth (blood)</term><term>Antigens, Helminth (genetics)</term><term>Antigens, Helminth (immunology)</term><term>Brugia malayi (immunology)</term><term>Cytokines (biosynthesis)</term><term>Cytokines (genetics)</term><term>DNA, Helminth (immunology)</term><term>Diffusion Chambers, Culture</term><term>Disease Models, Animal</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Gerbillinae</term><term>Helminth Proteins (genetics)</term><term>Helminth Proteins (immunology)</term><term>Immunity, Cellular</term><term>Immunization (methods)</term><term>Lymphocyte Activation</term><term>Male</term><term>Recombinant Proteins (genetics)</term><term>Recombinant Proteins (immunology)</term><term>Th2 Cells (immunology)</term><term>Vaccines (immunology)</term><term>Vaccines, DNA (immunology)</term><term>Vaccines, Synthetic (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN des helminthes (immunologie)</term><term>Activation des lymphocytes</term><term>Animaux</term><term>Anticorps antihelminthe (biosynthèse)</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe (génétique)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia malayi (immunologie)</term><term>Chambres de culture à diffusion</term><term>Cytokines (biosynthèse)</term><term>Cytokines (génétique)</term><term>Filariose lymphatique ()</term><term>Gerbillinae</term><term>Immunisation ()</term><term>Immunité cellulaire</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Protéines d'helminthes (génétique)</term><term>Protéines d'helminthes (immunologie)</term><term>Protéines recombinantes (génétique)</term><term>Protéines recombinantes (immunologie)</term><term>Vaccins (immunologie)</term><term>Vaccins synthétiques (immunologie)</term><term>Vaccins à ADN (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Helminth</term><term>Cytokines</term><term>Helminth Proteins</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>DNA, Helminth</term><term>Helminth Proteins</term><term>Recombinant Proteins</term><term>Vaccines</term><term>Vaccines, DNA</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Cytokines</term><term>Protéines d'helminthes</term><term>Protéines recombinantes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>ADN des helminthes</term><term>Antigènes d'helminthe</term><term>Brugia malayi</term><term>Lymphocytes auxiliaires Th2</term><term>Protéines d'helminthes</term><term>Protéines recombinantes</term><term>Vaccins</term><term>Vaccins synthétiques</term><term>Vaccins à ADN</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Diffusion Chambers, Culture</term><term>Disease Models, Animal</term><term>Gerbillinae</term><term>Immunity, Cellular</term><term>Lymphocyte Activation</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Chambres de culture à diffusion</term><term>Filariose lymphatique</term><term>Gerbillinae</term><term>Immunisation</term><term>Immunité cellulaire</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Immunization of jirds with Bm-alt-2 elicited partial protection against challenge infection with the filarial parasite <italic>Brugia malayi</italic>. In this study, we initially compared the protective immune responses elicited following immunization with recombinant Bm-ALT-2 protein regimen and Bm-alt-2 DNA regimen. These studies showed that protein vaccination conferred approximately 75% protection compared to DNA vaccination that conferred only 57% protection. Analysis of the protective immune responses showed that the protein immunization promoted a Th2-biased response with an increase in IL-4, IL-5 and IgG1 responses, whereas, the DNA vaccine promoted a Th1-biased response with profound IFN-γ and IgG2a responses. Since protein vaccination gave better results than DNA vaccination, we then wanted to evaluate whether a prime-boost vaccination that combined DNA prime and protein boost will significantly increase the protective responses induced by the protein vaccine. Our results suggest that prime-boost vaccination had no added advantage and was comparatively less effective (64% protection) than the Bm-ALT-2 protein alone vaccination. Prime boost vaccination generated mixed Th1/Th2 responses with a slightly diminished Th2 responses compared to protein vaccination. Thus, our results suggest that Bm-ALT-2 protein vaccination regimen may be slightly better than prime-boost vaccine regimen and the mechanism of protection appears to be largely mediated by a Th2-biased response.</p></div></front></TEI><affiliations><list><country><li>Inde</li><li>États-Unis</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Thirugnanam, Sivasakthivel" sort="Thirugnanam, Sivasakthivel" uniqKey="Thirugnanam S" first="Sivasakthivel" last="Thirugnanam">Sivasakthivel Thirugnanam</name></noRegion><name sortKey="Kaliraj, Perumal" sort="Kaliraj, Perumal" uniqKey="Kaliraj P" first="Perumal" last="Kaliraj">Perumal Kaliraj</name><name sortKey="Murugan, Vadivel" sort="Murugan, Vadivel" uniqKey="Murugan V" first="Vadivel" last="Murugan">Vadivel Murugan</name><name sortKey="Nandakumar, Krithika" sort="Nandakumar, Krithika" uniqKey="Nandakumar K" first="Krithika" last="Nandakumar">Krithika Nandakumar</name><name sortKey="Pandiaraja, Pandurangan" sort="Pandiaraja, Pandurangan" uniqKey="Pandiaraja P" first="Pandurangan" last="Pandiaraja">Pandurangan Pandiaraja</name><name sortKey="Reddy, Maryada Venkata Rami" sort="Reddy, Maryada Venkata Rami" uniqKey="Reddy M" first="Maryada Venkata Rami" last="Reddy">Maryada Venkata Rami Reddy</name></country><country name="États-Unis"><noRegion><name sortKey="Ramaswamy, Kalyanasundaram" sort="Ramaswamy, Kalyanasundaram" uniqKey="Ramaswamy K" first="Kalyanasundaram" last="Ramaswamy">Kalyanasundaram Ramaswamy</name></noRegion><name sortKey="Gnanasekar, Munirathinam" sort="Gnanasekar, Munirathinam" uniqKey="Gnanasekar M" first="Munirathinam" last="Gnanasekar">Munirathinam Gnanasekar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007367 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007367 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2763209
|texte= Brugia malayi: Comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:17442307" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |